原发性胃平滑肌肉瘤中DNA倍体的预后价值

Prognostic value of DNA ploidy in primary gastric leiomyosarcoma.

作者信息

Suzuki H, Sugihira N

机构信息

Second Department of Surgery, Mie University School of Medicine, Tsu City, Japan.

出版信息

Br J Surg. 1993 Dec;80(12):1549-50. doi: 10.1002/bjs.1800801219.

DOI:10.1002/bjs.1800801219

PMID:8298922

Abstract

The prognostic value of DNA ploidy was evaluated in 25 patients with primary gastric leiomyosarcoma, using paraffin-embedded archival specimens analysed by DNA flow cytometry. Ploidy patterns were diploid in ten tumours and non-diploid in 15. They did not correlate with clinicopathological features of the lesions such as tumour size and grade or mitotic index. A non-diploid pattern was associated with a significantly reduced patient survival rate (P < 0.05), as was higher tumour grade (P < 0.01). Neither tumour size nor mitotic index correlated with patient survival.

摘要

采用DNA流式细胞术对25例原发性胃平滑肌肉瘤患者石蜡包埋存档标本进行分析，评估DNA倍体的预后价值。10例肿瘤的倍体模式为二倍体，15例为非二倍体。它们与肿瘤大小、分级或有丝分裂指数等病变的临床病理特征无关。非二倍体模式与患者生存率显著降低相关（P<0.05），肿瘤分级较高也与之相关（P<0.01）。肿瘤大小和有丝分裂指数均与患者生存率无关。