Elias S, Abbas B, el San-Ousi S M
Department of Veterinary Medicine, Pharmacology and Toxicology, Faculty of Veterinary Science, University of Khartoum, Sudan.
Br Vet J. 1993 Sep-Oct;149(5):485-93. doi: 10.1016/S0007-1935(05)80113-7.
Nubian goats were experimentally infected with Corynebacterium renale type II by either the intravenous or intraurethral routes using infection rates of 1.75 x 10(10), 7.08 x 10(19) or 5 x 10(23) organisms. All inoculated goats were anorexic, lost weight and became dull or depressed. Albuminuria, pyuria and epithelial casts were noted in the urine. Following intravenous challenge the animals showed a dose-related elevation of serum ammonia, urea, and creatinine with significant changes in haemoglobin concentration, packed cell volume and leucocyte counts. A mild to severe (sometimes haemorrhagic) cystitis and urethritis and a mild nephrosis were noted post mortem and mucoserous or mucogelatinous non-purulent discharges were present in the renal pelvis. The findings are compared to the naturally occurring C. renale pyelonephritis in cattle and the suitability of the goat as a model for that disease is discussed.
使用1.75×10¹⁰、7.08×10¹⁹或5×10²³个菌体，通过静脉内或尿道内途径对努比亚山羊进行实验性感染II型肾棒状杆菌。所有接种的山羊均出现厌食、体重减轻，并变得迟钝或抑郁。尿液中出现蛋白尿、脓尿和上皮管型。静脉内攻击后，动物血清氨、尿素和肌酐呈剂量相关升高，血红蛋白浓度、红细胞压积和白细胞计数有显著变化。死后尸检发现轻度至重度（有时为出血性）膀胱炎和尿道炎以及轻度肾病，肾盂中有黏液浆液性或黏液胶冻状非脓性分泌物。将这些发现与牛自然发生的肾棒状杆菌肾盂肾炎进行了比较，并讨论了山羊作为该疾病模型的适用性。
