他莫昔芬对绝经后乳腺癌女性血浆脂质和脂蛋白的影响。
Effect of tamoxifen on plasma lipids and lipoproteins in postmenopausal women with breast cancer.
作者信息
Thangaraju M, Kumar K, Gandhirajan R, Sachdanandam P
机构信息
Department of Medical Biochemistry, University of Madras, India.
出版信息
Cancer. 1994 Feb 1;73(3):659-63. doi: 10.1002/1097-0142(19940201)73:3<659::aid-cncr2820730325>3.0.co;2-h.
BACKGROUND
Adjuvant tamoxifen therapy is given to large and increasing numbers of women with early-stage breast cancer. The effects of this drug on plasma lipids and lipoprotein profiles are important, because cardiovascular disease also develops over time in a large percentage of tamoxifen-treated postmenopausal women. The purpose of the study was to evaluate the effects of tamoxifen on plasma lipid and lipoprotein profiles in postmenopausal Indian women who were disease-free after primary treatment for breast cancer.
METHODS
A short-term evaluation of 6 months of tamoxifen therapy (10 mg twice a day) in 45 postmenopausal women was conducted. The plasma lipids and lipoprotein levels were evaluated before and after 3 and 6 months of tamoxifen treatment.
RESULTS
At 3 and 6 months' evaluation, patients receiving tamoxifen showed significantly decreased levels of total cholesterol, free cholesterol, and low-density lipoprotein cholesterol (P < 0.001 for each) and increased levels of plasma triglycerides, free fatty acids, very low density lipoprotein cholesterol, and high-density lipoprotein cholesterol.
CONCLUSION
The results suggest that tamoxifen therapy benefits postmenopausal patients with breast cancer, with likely reduction in the risk of cardiovascular disease.
背景
大量且数量不断增加的早期乳腺癌女性接受他莫昔芬辅助治疗。这种药物对血脂和脂蛋白谱的影响很重要，因为在很大比例接受他莫昔芬治疗的绝经后女性中，心血管疾病也会随着时间推移而发生。本研究的目的是评估他莫昔芬对乳腺癌初次治疗后无疾病的绝经后印度女性血脂和脂蛋白谱的影响。
方法
对45名绝经后女性进行了为期6个月的他莫昔芬治疗（每日两次，每次10毫克）的短期评估。在他莫昔芬治疗3个月和6个月前后评估血脂和脂蛋白水平。
结果
在3个月和6个月评估时，接受他莫昔芬治疗的患者总胆固醇、游离胆固醇和低密度脂蛋白胆固醇水平显著降低（每项P < 0.001），血浆甘油三酯、游离脂肪酸、极低密度脂蛋白胆固醇和高密度脂蛋白胆固醇水平升高。
结论
结果表明，他莫昔芬治疗对绝经后乳腺癌患者有益，可能降低心血管疾病风险。
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