胰高血糖素在人类糖尿病酮症酸中毒中的作用：使用生长抑素的研究
Role of glucagon in human diabetic ketoacidosis: studies using somatostatin.
作者信息
Gerich J E, Schneider V S, Lorenzi M, Tsalikian E, Karam J H, Bier D M, Forsham P H
出版信息
Clin Endocrinol (Oxf). 1976;5 Suppl:299S-305S. doi: 10.1111/j.1365-2265.1976.tb03838.x.
Abstract
The present studies demonstrate that endogenous glucagon is hyperglycaemic, lipolytic and ketogenic in man, and that insulin deficiency is necessary, but is in itself not sufficient, to cause fulminant diabetic ketoacidosis. Furthermore, continuous elevation of endogenous glucagon secretion appears to be necessary for the maintenance and continued development of the characteristic metabolic consequences of insulin lack.
摘要
目前的研究表明，内源性胰高血糖素在人体中具有升血糖、分解脂肪和生酮作用，且胰岛素缺乏是引发暴发性糖尿病酮症酸中毒的必要条件，但仅胰岛素缺乏本身并不足以导致该病。此外，内源性胰高血糖素分泌持续升高似乎是维持和持续发展胰岛素缺乏所特有的代谢后果的必要条件。
Zotero 插件