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Antibody-guided scintigraphy: targeting of the "magic bullet".

作者信息

Fazio F, Paganelli G

机构信息

INB-CNR, University of Milan, Scientific Institute H San Raffaele, Italy.

出版信息

Eur J Nucl Med. 1993 Dec;20(12):1138-40. doi: 10.1007/BF00171010.

DOI:10.1007/BF00171010
PMID:8299647
Abstract
摘要

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Antibody-guided scintigraphy: targeting of the "magic bullet".抗体导向闪烁扫描术:“神奇子弹”的靶向作用
Eur J Nucl Med. 1993 Dec;20(12):1138-40. doi: 10.1007/BF00171010.
2
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[Radioimmunoscintigraphy: fundamentals (1)].[放射免疫闪烁显像:基础(1)]
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Immunoscintigraphy for cancer detection: "a thousand ills require a thousand cures".用于癌症检测的免疫闪烁扫描术:“千病需千治”。
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The radioimmunoguided surgery (RIGS) system as a diagnostic tool.
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Cancer imaging with radiolabeled antibodies: new advances with technetium-99m-labeled monoclonal antibody Fab' fragments, especially CEA-Scan and prospects for therapy.用放射性标记抗体进行癌症成像:锝-99m标记的单克隆抗体Fab'片段的新进展,特别是CEA-Scan及治疗前景。
J Nucl Med Technol. 1997 Mar;25(1):18-23; quiz 34.
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A role for gamma scintigraphy in cancer immunology and immunotherapy.γ闪烁扫描术在癌症免疫学和免疫治疗中的作用。
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[Radioimmunoguided surgery. Presentation of the topic].[放射免疫导向手术。主题介绍]
Ann Ital Chir. 1991 May-Jun;62(3):227-9.

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Improving the efficacy of Photoimmunotherapy (PIT) using a cocktail of antibody conjugates in a multiple antigen tumor model.利用抗体偶联物鸡尾酒提高多抗原肿瘤模型中光免疫疗法(PIT)的疗效。
Theranostics. 2013 Apr 23;3(6):357-65. doi: 10.7150/thno.5908. Print 2013.
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Biochemical modifications of avidin improve pharmacokinetics and biodistribution, and reduce immunogenicity.抗生物素蛋白的生化修饰改善了药代动力学和生物分布,并降低了免疫原性。
Br J Cancer. 1998 Jul;78(2):189-97. doi: 10.1038/bjc.1998.463.
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Pretargeted immunoscintigraphy in patients with medullary thyroid carcinoma.

本文引用的文献

1
Use of radiolabelled monoclonal anti-CEA antibodies for the detection of human carcinomas by external photoscanning and tomoscintigraphy.使用放射性标记的抗癌胚抗原单克隆抗体通过体外光扫描和断层闪烁扫描检测人类癌症。
Immunol Today. 1981 Dec;2(12):239-49. doi: 10.1016/0167-5699(81)90011-6.
2
The zone of activity of antibodies as determined by the use of radioactive tracers; the zone of activity of nephritoxic antikidney serum.通过使用放射性示踪剂所确定的抗体活性区;肾毒性抗肾血清的活性区。
J Immunol. 1948 Jun;59(2):141-6.
3
Imaging of melanoma with L-131-labeled monoclonal antibodies.
甲状腺髓样癌患者的预靶向免疫闪烁显像
Br J Cancer. 1996 Sep;74(5):825-31. doi: 10.1038/bjc.1996.443.
用L-131标记的单克隆抗体对黑色素瘤进行成像。
J Nucl Med. 1983 Feb;24(2):123-9.
4
Conjugation of antibodies with bifunctional chelating agents: isothiocyanate and bromoacetamide reagents, methods of analysis, and subsequent addition of metal ions.抗体与双功能螯合剂的偶联:异硫氰酸酯和溴乙酰胺试剂、分析方法以及随后金属离子的添加
Anal Biochem. 1984 Oct;142(1):68-78. doi: 10.1016/0003-2697(84)90517-7.
5
Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.抗生物素蛋白-生物素-过氧化物酶复合物(ABC)在免疫过氧化物酶技术中的应用:ABC法与未标记抗体(PAP)法的比较。
J Histochem Cytochem. 1981 Apr;29(4):577-80. doi: 10.1177/29.4.6166661.
6
Targeting of iodine-123-labelled tumour-associated monoclonal antibodies to ovarian, breast, and gastrointestinal tumours.将碘-123标记的肿瘤相关单克隆抗体靶向卵巢、乳腺和胃肠道肿瘤。
Lancet. 1982 Nov 6;2(8306):999-1005. doi: 10.1016/s0140-6736(82)90046-0.
7
Imaging with 131I-labeled monoclonal antibodies to a high-molecular-weight melanoma-associated antigen in patients with melanoma: efficacy of whole immunoglobulin and its F(ab')2 fragments.用131I标记的针对高分子量黑色素瘤相关抗原的单克隆抗体对黑色素瘤患者进行成像:完整免疫球蛋白及其F(ab')2片段的疗效
Cancer Res. 1985 Jul;45(7):3378-87.
8
Pharmacokinetics and antibodies.药代动力学与抗体。
J Nucl Med. 1987 Aug;28(8):1358-62.
9
Investigations of avidin and biotin for imaging applications.
J Nucl Med. 1987 Aug;28(8):1294-302.
10
Limitations of radiolabeled monoclonal antibodies for localization of human neoplasms.用于人类肿瘤定位的放射性标记单克隆抗体的局限性。
Cancer Res. 1986 Jun;46(6):3183-91.