原代培养的肝实质细胞（肝细胞）产生白细胞介素-1 。
Production of interleukin-1 by primary cultured parenchymal liver cells (hepatocytes).
作者信息
Tsukui T, Kikuchi K, Mabuchi A, Sudo T, Sakamoto T, Asano G, Yokomuro K
机构信息
Department of Microbiology and Immunology, Nippon Medical School, Tokyo, Japan.
出版信息
Exp Cell Res. 1994 Feb;210(2):172-6. doi: 10.1006/excr.1994.1026.
The production of interleukin-1 (IL-1) by cultured parenchymal liver cells was revealed by a biological assay with an IL-1-dependent cell line, Northern blot analysis, and in situ hybridization. Inhibition experiments on the IL-1 activity with anti IL-1 alpha antibody also support the presence of IL-1 alpha in the supernatant of cultured parenchymal liver cells. Based on these results, we discuss the possibility of IL-1 production by parenchymal liver cells in vivo.
通过使用白细胞介素-1（IL-1）依赖细胞系的生物测定、Northern印迹分析和原位杂交，揭示了培养的肝实质细胞可产生IL-1。用抗IL-1α抗体对IL-1活性进行的抑制实验也支持培养的肝实质细胞上清液中存在IL-1α。基于这些结果，我们讨论了肝实质细胞在体内产生IL-1的可能性。
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