The use of a shared donor oocyte program to evaluate the effect of uterine senescence.

作者信息

Check J H, Askari H A, Fisher C, Vanaman L

机构信息

Department of Obstetrics and Gynecology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Cooper Hospital/University Medical Center, Camden.

出版信息

Fertil Steril. 1994 Feb;61(2):252-6. doi: 10.1016/s0015-0282(16)56512-1.

DOI:10.1016/s0015-0282(16)56512-1

PMID:8299778

Abstract

OBJECTIVE

To determine if there is reduced uterine receptivity after age 40 by the comparison of pregnancy rates (PRs) of donor oocyte recipients > or = 40 years to those under age 40.

SETTING

In vitro fertilization-ET facility of a university-based practice, Cooper Institute for In Vitro Fertilization.

PATIENTS

All patients registering for the shared donor oocyte program from November 1990 to September 1992. Most recipients were in ovarian failure.

INTERVENTIONS

Donors were treated with luteal phase leuprolide acetate (LA) and gonadotropins; recipients were treated with oral E2 in graduated doses and 50 mg IM daily P. Endometrial thickness was considered in the decision to continue with transfer or to freeze all embryos.

MAIN OUTCOME MEASURES

Pregnancy rates per transfer in recipients and live birth rates according to age > or = 40 or < 40.

RESULTS

The clinical PR per transfer was 29.2% for the younger women and 25.4% for the older recipients. The live birth rate was 29.2% for the younger women and 22.4% for the older recipients.

CONCLUSIONS

These data support the conclusion that, if there is a decline in uterine receptivity for embryo implantation with advancing age, it is at least remediable with hormonal adjustments.

摘要