Miyazaki K, Horibe T, Antonucci J M, Takagi S, Chow L C
Department of Dental Materials and Devices, Fukuoka Dental College, Japan.
Dent Mater. 1993 Jan;9(1):41-5. doi: 10.1016/0109-5641(93)90104-x.
Chemical and mechanical properties of water-based polymeric calcium phosphate cements (PCPC) were investigated. These cements were derived from mixing several types of water-soluble polymers, e.g., gelatin, poly(vinyl alcohol) (PVA), and poly(alkenoic acids) such as poly(acrylic acid), with a calcium phosphate cement (CPC) mixture consisting of equimolar amounts of tetracalcium phosphate (TTCP) and anhydrous dicalcium phosphate (DCPA) as well as several other TTCP-containing mixtures. Cement formation was observed with all of the PCPCs. With the gelatin and PVA cements, significant amounts of hydroxyapatite (HA) formation were observed within 24 h. Their setting times and mechanical properties were similar to those of the purely inorganic CPC that is derived from the reaction of TTCP and DCPA in water. Although the mechanical properties of a gelatin-CPC cement were only slightly improved, its handling characteristics were superior to that of CPC. Significantly faster setting and stronger cements were obtained using polycarboxylic acid polymers with CPC. However, only small amounts of HA were observed in these types of polymeric cements even after 1 mon storage in distilled water at 37 degrees C. This research demonstrates the feasibility of preparing several new types of dental cements based on the interaction of water-soluble polymers with a self-setting calcium phosphate powder mixture.
研究了水基聚合物磷酸钙骨水泥（PCPC）的化学和力学性能。这些骨水泥是通过将几种水溶性聚合物（如明胶、聚乙烯醇（PVA））以及聚（丙烯酸）等聚（链烯酸）与由等摩尔量的磷酸四钙（TTCP）和无水磷酸二钙（DCPA）组成的磷酸钙骨水泥（CPC）混合物以及其他几种含TTCP的混合物混合而成。所有的PCPC都观察到了骨水泥的形成。对于明胶和PVA骨水泥，在24小时内观察到大量羟基磷灰石（HA）的形成。它们的凝结时间和力学性能与由TTCP和DCPA在水中反应得到的纯无机CPC相似。虽然明胶-CPC骨水泥的力学性能仅略有改善，但其操作特性优于CPC。使用聚羧酸聚合物与CPC可得到凝结速度明显更快且强度更高的骨水泥。然而，即使在37℃的蒸馏水中储存1个月后，在这些类型的聚合物骨水泥中也仅观察到少量的HA。本研究证明了基于水溶性聚合物与自凝磷酸钙粉末混合物的相互作用制备几种新型牙科骨水泥的可行性。
