一种可被小鼠抗重组牛生长激素抗血清识别的免疫显性连续表位。
An immuno-dominant sequential epitope recognized by mouse anti-recombinant bovine growth hormone antisera.
作者信息
Beattie J, Borromeo V, Fawcett H A, Secchi C
机构信息
Hannah Research Institute, Ayr, Scotland, UK.
出版信息
Immunol Lett. 1993 Sep;38(1):41-5. doi: 10.1016/0165-2478(93)90116-j.
PMID:8300153
Abstract
The sequential epitopes on bovine growth hormone (bGH) recognised by five polyclonal mouse antisera have been identified by scanning with multiple pin-bound peptides. Four main epitopes were identified at residues 29-40, 101-110, 139-152 and 181-191. Of these, only epitope 139-152 is recognised by all five mouse antisera indicating that, for the mouse, this may represent an immuno-dominant region of the bGH molecule.
摘要
通过用多种固定在针上的肽进行扫描，已确定了五种多克隆小鼠抗血清所识别的牛生长激素（bGH）上的连续表位。在第29 - 40位、101 - 110位、139 - 152位和181 - 191位残基处确定了四个主要表位。其中，只有139 - 152表位能被所有五种小鼠抗血清识别，这表明对于小鼠而言，这可能代表bGH分子的一个免疫优势区域。
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