Fukuda K, Fujino T, Oguma T, Hamajima F
Department of Parasitology, National Defense Medical College, Tokorozawa, Japan.
Int J Parasitol. 1993 Sep;23(6):757-63. doi: 10.1016/0020-7519(93)90072-7.
Inflammatory reactions to the lung fluke, Paragonimus westermani, in an abnormal host, the rat, were studied by electron microscopy. Inflammatory cells accumulated around the worms in rat muscles, but the reaction varied significantly in intensity as well as distribution of inflammatory cells from worm to worm in the same and different hosts. In an accumulation of inflammatory infiltrates around the worm, eosinophils were more commonly seen, and neutrophils and macrophages were fewer in number. Mast cells appeared rarely. Where inflammatory cells touched to the worms, the tegument of the worms was covered with moderately electron-dense flocculent material which included dense granules. This material, which probably consisted of immune complexes of host antibody and antigen secreted from tegumental granules, seemed to block the inflammatory cells from adhering to the worm surfaces. Inflammatory cells made direct contact with worm surfaces where flocculent material was absent. Dense secretory material was discharged from some eosinophils as a result of degranulation.
利用电子显微镜研究了肺吸虫卫氏并殖吸虫在异常宿主大鼠体内引起的炎症反应。炎症细胞在大鼠肌肉内的虫体周围积聚，但在同一宿主和不同宿主中，不同虫体周围炎症反应的强度及炎症细胞的分布差异显著。在虫体周围的炎性浸润聚集中，嗜酸性粒细胞更为常见，中性粒细胞和巨噬细胞数量较少。肥大细胞很少出现。当炎性细胞与虫体接触时，虫体的皮层被中度电子致密的絮状物质覆盖，其中包括致密颗粒。这种物质可能由宿主抗体与皮层颗粒分泌的抗原形成的免疫复合物组成，似乎阻止了炎性细胞黏附于虫体表面。在没有絮状物质的部位，炎性细胞与虫体表面直接接触。一些嗜酸性粒细胞脱颗粒后释放出致密的分泌物质。
