鸡蛔虫中鞘磷脂的合成

Sphingomyelin synthesis in Ascaridia galli.

作者信息

Bankov I, Barrett J

机构信息

Institute of Parasitology, Bulgarian Academy of Sciences, Sofia.

出版信息

Int J Parasitol. 1993 Dec;23(8):1083-5. doi: 10.1016/0020-7519(93)90131-h.

DOI:10.1016/0020-7519(93)90131-h

PMID:8300303

Abstract

Adult Ascaridia galli incorporate label from [U-14C] serine into various intermediates of sphingomyelin synthesis (ketosphinganine, sphinganine, sphingosine, ceramide and sphingomyelin). From the results it is concluded that A. galli possesses the five enzymes involved in sphingomyelin synthesis, namely: serine palmitoyltransferase, 3-ketosphinganine reductase, flavoprotein sphinganine reductase, sphingosine acyltransferase and ceramide choline phosphotransferase.

摘要

成年鸡蛔虫将[U-14C]丝氨酸中的标记物整合到鞘磷脂合成的各种中间产物中（酮鞘氨醇、鞘氨醇、鞘脂醇、神经酰胺和鞘磷脂）。从结果可以得出结论，鸡蛔虫拥有参与鞘磷脂合成的五种酶，即：丝氨酸棕榈酰转移酶、3-酮鞘氨醇还原酶、黄素蛋白鞘氨醇还原酶、鞘脂醇酰基转移酶和神经酰胺胆碱磷酸转移酶。