Angold A, Worthman C W
Developmental Epidemiology Program, Duke University Medical Center, Durham, NC 27710-3454.
J Affect Disord. 1993 Oct-Nov;29(2-3):145-58. doi: 10.1016/0165-0327(93)90029-j.
A dramatic feature of the epidemiology of depression is the appearance of a 2:1 female excess of depression during adolescence. In childhood, rates of depression either do not differ between boys and girls or show a slight excess in boys. In this paper we review a number of lines of evidence that implicate the physical and hormonal developments of puberty in this change. We also argue that the analysis of pubertal change in the etiology of depression must take into account the fact that the causation of depression is almost certainly a complex process. In understanding such a process we suggest that developmental epidemiological studies will be of particular value.
抑郁症流行病学的一个显著特征是，在青春期，女性抑郁症患者比男性多出一倍。在儿童期，男孩和女孩的抑郁症发病率要么没有差异，要么男孩的发病率略高。在本文中，我们回顾了一系列证据，这些证据表明青春期的身体和激素发育与此变化有关。我们还认为，在分析抑郁症病因中的青春期变化时，必须考虑到抑郁症的病因几乎肯定是一个复杂过程这一事实。在理解这样一个过程时，我们认为发育流行病学研究将具有特别的价值。
