Di Lazzaro V, Restuccia D, Molinari M, Leggio M G, Nardone R, Fogli D, Tonali P
Department of Neurology, Catholic University, Rome, Italy.
J Neurol Neurosurg Psychiatry. 1994 Jan;57(1):108-10. doi: 10.1136/jnnp.57.1.108.
The excitability of the motor cortex to magnetic stimulation was evaluated in seven patients with cerebellar lesions (six patients with a unilateral lesion) and in 20 control subjects. Magnetic motor threshold was defined at rest. In all but one of the patients with a hemicerebellar lesion the threshold was higher in the motor cortex contralateral to the impaired hemicerebellum and the right/left threshold asymmetry was clearly greater than normal. In the patient with a lesion involving both cerebellar hemispheres the magnetic threshold was above the normal limit on both sides. The latencies of motor responses were normal in all patients. This increase in the magnetic threshold of the motor cortex functionally related to the impaired hemicerebellum suggests the existence of a facilitating tonic action of the cerebellum on central motor circuits that might act at the cortical, or spinal level, or both.
对7例小脑病变患者（6例单侧病变）和20名对照受试者进行了运动皮层对磁刺激的兴奋性评估。静息时定义磁运动阈值。除1例小脑半球病变患者外，其余所有小脑半球病变患者患侧小脑受损对侧运动皮层的阈值均较高，且左右阈值不对称明显大于正常。在双侧小脑半球均有病变的患者中，两侧磁阈值均高于正常范围。所有患者的运动反应潜伏期均正常。与受损小脑半球功能相关的运动皮层磁阈值升高提示，小脑对中枢运动回路存在促进性紧张性作用，可能作用于皮层或脊髓水平，或两者皆有。
