Sachs G, Spiess K, Moser G, Kautzky A, Luger A, Pietschmann P, Schernthaner G S, Prager R
Dept of Psychiatry, University of Vienna, Austria.
J Psychosom Res. 1993 Dec;37(8):831-41. doi: 10.1016/0022-3999(93)90172-c.
The aim of the present study was to examine, whether individual emotional arousal induced by a specific stress interview may effect growth hormone (GH), cortisol, catecholamine and blood glucose levels in diabetes patients. To test the validity of this hypothesis we subjected 18 Type 1 diabetics and 18 healthy controls to a life event interview which produces individual arousal. During this stress interview catecholamines and plasma cortisol levels showed no significant increase, whereas there was a significant increase of GH over time in both group (p < 0.04), with a trend in diabetics to have a more marked GH response than controls (p < 0.10). Blood glucose levels remained unaffected by the interview. Depressed diabetics showed significantly higher cortisol increases (p < 0.004) than non-depressed diabetics, whereas there was no difference among depressed and non-depressed controls. Depression was not associated with an increase of other hormones or blood glucose levels in both groups. The results of our study confirm specific pathways in which individual emotional arousal and depression may lead to chronic metabolic disturbances as a result of GH and cortisol hypersecretion.
本研究的目的是检验由特定应激访谈诱发的个体情绪唤醒是否会影响糖尿病患者的生长激素（GH）、皮质醇、儿茶酚胺和血糖水平。为了验证这一假设的有效性，我们让18名1型糖尿病患者和18名健康对照者接受了一次能产生个体唤醒的生活事件访谈。在这次应激访谈期间，儿茶酚胺和血浆皮质醇水平没有显著升高，而两组中GH水平均随时间显著升高（p < 0.04），糖尿病患者的GH反应比对照组更明显，呈一种趋势（p < 0.10）。血糖水平不受访谈影响。抑郁的糖尿病患者的皮质醇升高幅度显著高于非抑郁的糖尿病患者（p < 0.004），而抑郁和非抑郁的对照组之间没有差异。在两组中，抑郁与其他激素或血糖水平的升高均无关。我们的研究结果证实了个体情绪唤醒和抑郁可能通过GH和皮质醇分泌过多导致慢性代谢紊乱的特定途径。
