Kasahara H, Tanno M, Yamada H, Endoh K, Kobayashi M, Karasawa A
Department of Psychiatry, Jikei University, School of Medicine.
Nihon Ronen Igakkai Zasshi. 1993 Oct;30(10):892-900. doi: 10.3143/geriatrics.30.892.
In order to characterize age-related and chronological changes of the brain, longitudinal studies of aged volunteers were conducted using computed tomography since 1982. The present paper discusses correlations between brain function and findings of MR images which were obtained a using 1.5 T superconductive MR instrument since 1989. A total of 118 volunteers aged 60 to 88 years old with a mean age of 75.0 +/- 6.7 participated in the study, which consisted of MRI, EEG recording, the Benton Visual Retention Test and a medical interview. Subjects with a past history or clinical evidence of CVD, head trauma or dementia were excluded from the study. Incidence of T2 high signal intensity lesions increased with age. Some showing T1 low signal intensity in the same lesion were considered to be lacunar infarction, over all incidence of which was 24.6%. Numbers of correct responses on the BVRT showed a negative correlation with numbers of T2 high signal intensity lesions. Although the aged volunteers in the present study could achieve all activity of daily living without any trouble, high cortical function evaluated by visuoperceptual performance of BVRT was somewhat disturbed in participants with multiple T2 high signal intensity lesions. Brain atrophy seems to be more advanced in groups with T2 hyper intensity lesions than in the group without them. These findings may support the notion that T2 high signal intensity lesions are not merely an index of ageing but pathologic lesions accompanied with senescence, although further studies including clinicopathological correlation are necessary to establish this concept.
为了描述大脑与年龄相关的变化以及随时间的变化，自1982年以来，使用计算机断层扫描对老年志愿者进行了纵向研究。本文讨论了自1989年以来使用1.5T超导磁共振仪器获得的脑功能与磁共振图像结果之间的相关性。共有118名年龄在60至88岁之间、平均年龄为75.0±6.7岁的志愿者参与了这项研究，该研究包括磁共振成像、脑电图记录、本顿视觉保持测试和一次医学访谈。有心血管疾病、头部外伤或痴呆病史或临床证据的受试者被排除在研究之外。T2高信号强度病变的发生率随年龄增加。同一病变中一些显示T1低信号强度的被认为是腔隙性梗死，其总体发生率为24.6%。BVRT上的正确反应数量与T2高信号强度病变的数量呈负相关。尽管本研究中的老年志愿者能够毫无困难地完成所有日常生活活动，但在有多个T2高信号强度病变的参与者中，通过BVRT的视觉感知表现评估的高级皮质功能受到了一定程度的干扰。有T2高信号强度病变的组脑萎缩似乎比没有病变的组更严重。这些发现可能支持这样一种观点，即T2高信号强度病变不仅仅是衰老的指标，而是伴随衰老的病理性病变，尽管需要包括临床病理相关性在内的进一步研究来确立这一概念。
