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[术中诊断嗜铬细胞瘤的麻醉管理——病例报告]

[Anesthetic management of intraoperatively diagnosed pheochromocytoma--a case report].

作者信息

Tsai P S, Wong K L

出版信息

Ma Zui Xue Za Zhi. 1993 Dec;31(4):267-72.

PMID:8302154
Abstract

Pheochromocytoma is a catecholamine secreting tumor originating from the adrenal medulla (up to 90%), or from the chromaffin tissue along the paravertebral sympathetic chain. The hallmark of pheochromocytoma is paroxysmal hypertension associated with diaphoresis, headache, tremulousness, and palpitations. The triad of diaphoresis, tachycardia, and headache in hypertensive patients is highly suggestive of pheochromocytoma. Other symptoms like flushing, nausea, vomiting, personality changes, and visual disturbances may however cast doubt on the diagnosis of pheochromocytoma. Death resulting from pheochromocytoma is usually due to congestive heart failure, myocardial infarction, or intracerebral hemorrhage. Although less than 0.1 percent of patients with hypertension have a pheochromocytoma, nearly 50 percent of the mortality with unsuspected pheochromocytoma occurred during anesthesia and surgery or parturition. Patients of unsuspected pheochromocytoma have higher risk for surgery, because some mandatory pre-op medical treatments might have been ignored. It is also a challenge to anesthesiologists to handle unsuspected hypertensive crisis during anesthesia and surgery. We presented such a case of unexpected Pheochromocytoma which was mis-diagnosed by the surgeon and was treated as an ordinary adrenal gland tumor and was scheduled for surgical operation. When the patient was undergoing excision of the tumor, manipulations of the tumor initiated an tremendous elevation of the blood pressure. Upon reviewing her history of normotension with visual disturbance, nausea and restlessness, she was immediate treated as with a pheochromocytoma. Appropriate managements were applied to control her abnormally high fluctuating blood pressure with success and with no complications or adverse effect.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

嗜铬细胞瘤是一种分泌儿茶酚胺的肿瘤,起源于肾上腺髓质(高达90%),或沿椎旁交感神经链的嗜铬组织。嗜铬细胞瘤的特征是阵发性高血压,伴有多汗、头痛、震颤和心悸。高血压患者出现多汗、心动过速和头痛三联征强烈提示嗜铬细胞瘤。然而,其他症状如脸红、恶心、呕吐、性格改变和视觉障碍可能会对嗜铬细胞瘤的诊断产生怀疑。嗜铬细胞瘤导致的死亡通常是由于充血性心力衰竭、心肌梗死或脑出血。虽然高血压患者中不到0.1%患有嗜铬细胞瘤,但未被怀疑的嗜铬细胞瘤患者近50%的死亡发生在麻醉、手术或分娩期间。未被怀疑患有嗜铬细胞瘤的患者手术风险更高,因为一些必要的术前医疗治疗可能被忽视了。在麻醉和手术期间处理未被怀疑的高血压危象对麻醉医生来说也是一个挑战。我们报告了这样一例意外的嗜铬细胞瘤病例,该病例被外科医生误诊,被当作普通肾上腺肿瘤并安排手术。当患者在进行肿瘤切除时,对肿瘤的操作引发了血压的大幅升高。回顾她有正常血压但伴有视觉障碍、恶心和烦躁不安的病史后,她立即被当作嗜铬细胞瘤进行治疗。采取了适当的处理措施成功控制了她异常波动的高血压,且无并发症或不良反应。(摘要截选至250词)

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