Juretić D, Cvoriscec D, Vuković-Holjevac A, Benković J, Lipovac K, Stavljenić A
Institute for Medical Biochemistry, Faculty of Pharmacy and Biochemistry, University of Zagreb, Croatia.
Nephron. 1993;65(4):564-7. doi: 10.1159/000187564.
The relationship between glycosaminoglycans and beta 2-microglobulin, glycosaminoglycans and N-acetyl-beta-D-glucosaminidase as well as the relationship between the chondroitin sulfate/heparan sulfate ratio and SDS electrophoresis in the urine of subjects from the endemic area of Balkan nephropathy was studied in order to establish a method for early detection of this disease. The results show an unquestionable increase in urinary excretion of total glycosaminoglycans in subjects with or suspected of having Balkan endemic nephropathy while the chondroitin sulfate/heparan sulfate ratio was not statistically different between the groups studied. Thus, the chondroitin sulfate/heparan sulfate ratio cannot be used as a cheap and quick semiquantitative method for the diagnosis of early tubular damage in Balkan endemic nephropathy. However, the determination of total glycosaminoglycans in the urine of subjects from endemic areas proved to be valuable additional information helping with the diagnosis of Balkan endemic nephropathy.
为建立巴尔干地方性肾病早期检测方法，研究了来自巴尔干地方性肾病流行地区受试者尿液中糖胺聚糖与β2-微球蛋白、糖胺聚糖与N-乙酰-β-D-氨基葡萄糖苷酶的关系，以及硫酸软骨素/硫酸乙酰肝素比值与SDS电泳的关系。结果显示，患有或疑似患有巴尔干地方性肾病的受试者尿中总糖胺聚糖排泄量无疑增加，而所研究的组间硫酸软骨素/硫酸乙酰肝素比值无统计学差异。因此，硫酸软骨素/硫酸乙酰肝素比值不能作为诊断巴尔干地方性肾病早期肾小管损伤的廉价快速半定量方法。然而，测定流行地区受试者尿液中的总糖胺聚糖被证明是有助于诊断巴尔干地方性肾病的有价值的附加信息。
