铜缺乏引起的高胆固醇血症与谷胱甘肽代谢及肝脏HMG-CoA还原酶的调节有关。
Hypercholesterolemia of copper deficiency is linked to glutathione metabolism and regulation of hepatic HMG-CoA reductase.
作者信息
Bunce G E
机构信息
Department of Biochemistry and Nutrition, Virginia Polytechnic Institute, Blacksburg 24061.
出版信息
Nutr Rev. 1993 Oct;51(10):305-7. doi: 10.1111/j.1753-4887.1993.tb03061.x.
Abstract
Copper deficiency in rats causes hypercholesterolemia and increases in hepatic glutathione concentration and HMG-CoA reductase activity. Prevention of the increase in hepatic glutathione abolished the other changes.
摘要
大鼠体内铜缺乏会导致高胆固醇血症，并使肝脏谷胱甘肽浓度和HMG - CoA还原酶活性增加。阻止肝脏谷胱甘肽浓度的升高可消除其他变化。
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