几种类型肾小球肾炎中内脏上皮细胞上常见急性淋巴细胞白血病抗原的表达。

Common acute lymphoblastic leukemia antigen expression on visceral epithelial cells in several types of glomerulonephritis.

作者信息

Ivanov A, Paltsev M

机构信息

Department of Pathological Anatomy, Sechenov Medical Academy, Moscow, Russia.

出版信息

Pathol Res Pract. 1993 Sep;189(8):940-5. doi: 10.1016/s0344-0338(11)81106-4.

DOI:10.1016/s0344-0338(11)81106-4

PMID:8302714

Abstract

The distribution of a group of glomerular antigens and the composition of deposits was examined by immunoelectron microscopy in patients with idiopathic membranous nephropathy (MN), focal segmental glomerulosclerosis (FSG) and membranoproliferative glomerulonephritis (MPGN). The decrease in expression of common acute lymphoblastic leukemia antigen (CALLA) on glomerular visceral epithelial cells was found in MN and FSG. The loss of CALLA on visceral epithelial cells was typical for immature glomerulus and for this cell culture. On the strength of these results we can suppose that the dedifferentiation of visceral epithelial cells takes place in MN and FSG. It leads to changes in the synthesis of the glomerular basement membrane components.

摘要

通过免疫电子显微镜检查了特发性膜性肾病（MN）、局灶节段性肾小球硬化（FSG）和膜增生性肾小球肾炎（MPGN）患者的一组肾小球抗原分布及沉积物组成。在MN和FSG中发现肾小球脏层上皮细胞上常见急性淋巴细胞白血病抗原（CALLA）表达降低。脏层上皮细胞上CALLA的缺失在未成熟肾小球和这种细胞培养中是典型的。基于这些结果，我们可以推测MN和FSG中脏层上皮细胞发生了去分化。这导致肾小球基底膜成分合成的改变。