DiBonito L, Falconieri G, Bonifacio-Gori D
Department of Anatomic Pathology, University of Trieste, Italy.
Pathol Res Pract. 1993 Nov;189(9):1023-9. doi: 10.1016/S0344-0338(11)80675-8.
We have investigated 103 biopsy specimens obtained from 50 women (average 28.1 years, range 16-66) with multicentric condylomatosis of the genital tract, including the uterine cervix (48 samples), the vagina (23), and the vulva (32). Each patient had at least 2 biopsies. A positive in situ hybridization for a Human Papilloma Virus (HPV) cocktail was observed in samples from 38 patients: in these multiplicity of lesions regarded the cervix and vulva (22 cases), cervix and vagina (12), vulva and vagina (1), cervix, vulva and vagina (3). Viral types 6,11 were more prevalent in simple condylomata. Both low- and high grade lesions of cervix, vagina, and vulva showed prevalence of types 16, 18 and 31, 33, 35. Signaling for more than one probe cocktail was detected in 14 (13.6%) samples. Partner's condylomatosis was referred to by a sizeable minority of patients. It is concluded that the spectrum of HPV infection in the female genital tract reflects a multiplicity of factors, including involved viral type and site, immunitary reaction of the host, perpetration or reactivation of latent infections.
我们研究了从50名患有生殖道多中心湿疣的女性（平均年龄28.1岁，范围16 - 66岁）获取的103份活检标本，这些标本包括子宫颈（48份样本）、阴道（23份）和外阴（32份）。每位患者至少有2份活检标本。在38名患者的样本中观察到人乳头瘤病毒（HPV）混合探针原位杂交呈阳性：其中病变累及宫颈和外阴的有22例，宫颈和阴道的有12例，外阴和阴道的有1例，宫颈、外阴和阴道的有3例。病毒6型、11型在单纯湿疣中更为常见。宫颈、阴道和外阴的低级别及高级别病变均显示16、18型以及31、33、35型较为普遍。在14份（13.6%）样本中检测到不止一种探针混合液的信号。相当少数的患者提及性伴侣患有湿疣。得出的结论是，女性生殖道HPV感染谱反映了多种因素，包括所涉及的病毒类型和部位、宿主的免疫反应、潜伏感染的发生或重新激活。
