静态工作对纤维蛋白溶解和血小板功能的影响。

The impact of static work on fibrinolysis and platelet function.

作者信息

Vind J, Gleerup G, Nielsen P T, Winther K

机构信息

Department of Clinical Chemistry, Frederiksberg Hospital, University of Copenhagen, Denmark.

出版信息

Thromb Res. 1993 Dec 1;72(5):441-6. doi: 10.1016/0049-3848(93)90244-i.

DOI:10.1016/0049-3848(93)90244-i

PMID:8303686

Abstract

Brief stress such as dynamic work protects against thrombosis by enhancing blood fluidity. The effect of isometric work on blood fluidity, however, is not known. The aim of the present study therefore was to test the effect of isometric work on heart rate (HR), blood pressure (BP), platelet function and fibrinolytic activity. Twelve healthy male volunteers were tested before and after isometric work. Isometric work resulted in an increase in HR from 62.4 to 110.0 beats/min and in systolic BP from 118.3 to 134.5 mmHg (p < 0.01). No significant change occurred in platelet release estimated as plasma levels of B-TG and PF-4, or platelet aggregation induced by ADP. Fibrinolytic activity increased, as evidenced by a decrease in ECLT from 136.7 + 10.5 to 72.3 + 9.8 min) (p < 0.01) and an increase in t-PA of 400%. No significant change was observed in PAI. The present data suggest that isometric work increases fibrinolytic activity significantly, but leaves platelet function unchanged.

摘要

短暂应激如动态工作可通过增强血液流动性预防血栓形成。然而，等长工作对血液流动性的影响尚不清楚。因此，本研究的目的是测试等长工作对心率（HR）、血压（BP）、血小板功能和纤溶活性的影响。对12名健康男性志愿者在进行等长工作前后进行了测试。等长工作导致心率从62.4次/分钟增加到110.0次/分钟，收缩压从118.3 mmHg增加到134.5 mmHg（p<0.01）。以血浆β-血小板球蛋白（B-TG）和血小板第4因子（PF-4）水平估算的血小板释放量，或由二磷酸腺苷（ADP）诱导的血小板聚集均未发生显著变化。纤溶活性增加，表现为优球蛋白溶解时间（ECLT）从136.7±10.5分钟降至72.3±9.8分钟（p<0.01），组织型纤溶酶原激活物（t-PA）增加400%。纤溶酶原激活物抑制剂（PAI）未观察到显著变化。目前的数据表明，等长工作可显著增加纤溶活性，但对血小板功能无影响。