肝-肾中毒，其特征是给绵羊瘤胃内注射蛇草叶子（古铁雷斯属植物）后出现。

Hepato-renal toxicosis characterized in sheep dosed intraruminally with snakeweed foliage (Gutierrezia spp).

作者信息

Edrington T S, Ross T T, Smith G S, Hall L, Oetting B C, Williams J L

机构信息

Department of Animal and Range Sciences, New Mexico State University, Las Cruces 88003.

出版信息

Vet Hum Toxicol. 1993 Dec;35(6):506-8.

PMID:8303818

Abstract

To investigate the acute effects of snakeweed foliage (SW, Gutierrezia spp), 6 ruminally fistulated wethers (avg BW 78.6 kg) were dosed intraruminally (2/dose) with 454 g ground SW foliage, 227 g SW + 227 g alfalfa, or 454 g alfalfa daily for 5 d. Rumen fluid and blood samples were collected daily before SW dosage, and on day 6 the animals were euthanized and examined. At d 5, SW increased direct and indirect bilirubin indicating impaired hepatocyte function with biliary involvement and cholestasis. Gamma-glutamyl transpeptidase concentrations were elevated, and pale yellowish enlarged livers were observed in SW-dosed animals. Serum creatinine concentrations were increased 2-fold by SW, suggesting renal impairment. Rumens from dosed animals were compacted with hemorrhagic and necrotic mucosa suggesting SW-impaired rumen motility and microbial fermentation. One wether dosed with 454 g SW died after SW dosage for 2 d.

摘要

为研究蛇草（SW，节节草属）叶片的急性效应，选用6头装有瘤胃瘘管的阉羊（平均体重78.6千克），每天经瘤胃内给药（每次给药）454克磨碎的蛇草叶片、227克蛇草 + 227克苜蓿或454克苜蓿，持续5天。每天在给蛇草前采集瘤胃液和血液样本，在第6天对动物实施安乐死并进行检查。在第5天，蛇草使直接胆红素和间接胆红素升高，表明肝细胞功能受损且伴有胆汁淤积。γ-谷氨酰转肽酶浓度升高，在给予蛇草的动物中观察到肝脏肿大且呈淡黄色。蛇草使血清肌酐浓度增加了2倍，提示肾功能受损。给药动物的瘤胃紧实，黏膜有出血和坏死，表明蛇草损害了瘤胃蠕动和微生物发酵。一头给予454克蛇草的阉羊在给药2天后死亡。