Vetoshkina T V, Dubskaia T Iu
Vopr Med Khim. 1993 Nov-Dec;39(6):23-6.
Distinct alterations in the metabolism of lipids and phospholipids as well as activation of lipid peroxidation in liver tissue were detected in mice after administration of a new antitumoral drug cisplatin at a dose of LD50 (13.5 mg/kg) or after the course treatment within 5 days using 1/5 LD50. Content of malonic dialdehyde, diene conjugates and Schiff bases was increased, while the phospholipid composition was altered and concentration of membrane-toxic ingredients was increased. When the effects of cisplatin, administered at a dose of LD50 and during the course treatment, were analyzed more pronounced impairments of lipid metabolism were found during 7-15 days in mice treated with the drug at LD50. However, the drug toxic effect was manifested earlier during the course of treatment and in some cases it maintained for a long time (up to 30 days of the experiment). The data obtained suggest that correction of the cytostatic-induced impairments in liver tissue functions may be carried out by means of the anti-radical drugs.
给小鼠注射剂量为LD50（13.5毫克/千克）的新型抗肿瘤药物顺铂后，或在5天内使用1/5 LD50进行疗程治疗后，检测到肝脏组织中脂质和磷脂代谢的明显改变以及脂质过氧化的激活。丙二醛、二烯共轭物和席夫碱的含量增加，同时磷脂组成发生改变，膜毒性成分的浓度增加。当分析以LD50剂量给药和顺铂疗程治疗的效果时，发现在用LD50剂量药物治疗的小鼠中，在7至15天期间脂质代谢的损伤更为明显。然而，药物的毒性作用在治疗过程中出现得更早，并且在某些情况下会持续很长时间（长达实验的30天）。获得的数据表明，可以通过抗自由基药物来纠正细胞抑制剂诱导的肝脏组织功能损伤。
