Mironov P I, Vakhitov V A, Davletov E G
Vopr Med Khim. 1993 Nov-Dec;39(6):54-7.
Relationship was studied between the polymorphism of alpha 1-antitrypsin (Pi), haptoglobin (Hp) and transferrin and the development of chronic unspecific impairment of children lungs. Combination of protein isoforms PiM3M3 and Hp 1-1 was found to increase the risk of the lungs unspecific impairments in persons with lingering pneumonia and caused more severe development of the disease. Relatively low activity of the isoform PiM3M3, as compared with other forms of the PiMM system, and more intensive and nonadequate rate of lipid peroxidation in patients containing HP 1-1 appear to be responsible for aggravation of these impairments.
研究了α1-抗胰蛋白酶（Pi）、触珠蛋白（Hp）和转铁蛋白的多态性与儿童肺部慢性非特异性损伤发展之间的关系。发现PiM3M3和Hp 1-1蛋白异构体的组合会增加迁延性肺炎患者肺部非特异性损伤的风险，并导致疾病更严重的发展。与PiMM系统的其他形式相比，PiM3M3异构体活性相对较低，而含有HP 1-1的患者脂质过氧化速率更高且不适当，这似乎是这些损伤加重的原因。
