[重组人促红细胞生成素（rhuEPO）对长期血液透析患者血小板磷脂的影响]

[Effect of human recombinant erythropoietin (rhuEPO) on platelet phospholipids in chronically hemodialysed].

作者信息

Krawczyk W, Dmoszyńska A, Ledwozyw A, Soroka-Wojtaszko M

机构信息

Ośrodka Dializ przy Oddziale Chorób Wewnetrznych Szpitala Wojewódzkiego, Chełmie.

出版信息

Acta Haematol Pol. 1993;24(4):327-31.

PMID:8303978

Abstract

An important role in the formation of haemostasis defects in haemodialysed patients play phospholipids. The disturbances of platelet activity play an essential part in platelet structure and function. In uraemic patients changed plasma lipid pattern is observed, as well as positive influence of human recombinant erythropoietin (rhuEPO) on some plasma lipid disorders in these patients. The aim of this study was to investigate rhuEPO influence on platelet phospholipid composition in haemodialysed patients. RhuEPO was applied subcutaneously, 2000j twice a week. Before rhuEPO treatment significant decrease of phosphatidylethanolamine (PE), phosphatidylinositol (PI) and phosphatidylcholine (PC) contents was observed, as compared with control group. After rhuEPO treatment a significant increase of PE and PC contents was noted. The obtained results suggest that rhuEPO partially normalizes changed platelet phospholipids composition, but detailed mechanism of this influence is unclear.

摘要

磷脂在血液透析患者止血缺陷的形成中起重要作用。血小板活性紊乱在血小板结构和功能中起重要作用。在尿毒症患者中观察到血浆脂质模式的改变，以及重组人促红细胞生成素（rhuEPO）对这些患者某些血浆脂质紊乱的积极影响。本研究的目的是探讨rhuEPO对血液透析患者血小板磷脂组成的影响。rhuEPO皮下注射，每周两次，每次2000单位。与对照组相比，在rhuEPO治疗前观察到磷脂酰乙醇胺（PE）、磷脂酰肌醇（PI）和磷脂酰胆碱（PC）含量显著降低。rhuEPO治疗后，PE和PC含量显著增加。所得结果表明，rhuEPO可部分使改变的血小板磷脂组成正常化，但其影响的详细机制尚不清楚。