The isolation and characterization of clones of 4a-hydroxytetrahydrobiopterin dehydratase. - Suppr | 超能文献

The isolation and characterization of clones of 4a-hydroxytetrahydrobiopterin dehydratase.

作者信息

Kaufman S, Citron B A, Davis M, Milstien S

机构信息

Laboratory of Neurochemistry, National Institute of Mental Health, Betheada, MD 20892.

出版信息

Adv Exp Med Biol. 1993;338:97-102. doi: 10.1007/978-1-4615-2960-6_19.

DOI:10.1007/978-1-4615-2960-6_19

Abstract

摘要

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The isolation and characterization of clones of 4a-hydroxytetrahydrobiopterin dehydratase.

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Molecular cloning and recombinant expression of the human liver phenylalanine hydroxylase stimulating factor revealed structural and functional identity to the dimerization cofactor for the nuclear transcription factor HNF-1 alpha.人肝脏苯丙氨酸羟化酶刺激因子的分子克隆与重组表达显示，其与核转录因子HNF-1α的二聚化辅助因子在结构和功能上具有同一性。

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Identity of 4a-carbinolamine dehydratase, a component of the phenylalanine hydroxylation system, and DCoH, a transregulator of homeodomain proteins.苯丙氨酸羟化系统的一个组成部分4a-氨基甲醇脱水酶与同源结构域蛋白的反式调节因子DCoH的同一性。

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Mutation in the 4a-carbinolamine dehydratase gene leads to mild hyperphenylalaninemia with defective cofactor metabolism.4a-氨基甲醇胺脱水酶基因突变导致轻度高苯丙氨酸血症伴辅助因子代谢缺陷。

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Effects of dietary glycerol on the expression of pterin carbinolamine dehydratase in the rat.膳食甘油对大鼠蝶呤甲醇胺脱水酶表达的影响。

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Human pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor-1 alpha. Characterization and kinetic analysis of wild-type and mutant enzymes.人蝶呤-4α-羧胺脱水酶/肝细胞核因子-1α二聚化辅因子。野生型和突变型酶的特性及动力学分析。

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Human white blood cells and hair follicles are good sources of mRNA for the pterin carbinolamine dehydratase/dimerization cofactor of HNF1 for mutation detection.人白细胞和毛囊是用于检测突变的蝶呤甲醇胺脱水酶/HNF1二聚化辅助因子的mRNA的良好来源。

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The bifunctional DCOH protein binds to HNF1 independently of its 4-alpha-carbinolamine dehydratase activity.双功能DCOH蛋白独立于其4-α-氨基甲醇脱水酶活性与肝细胞核因子1（HNF1）结合。

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Identification of hepatic nuclear factor 1 binding sites in the 5' flanking region of the human phenylalanine hydroxylase gene: implication of a dual function of phenylalanine hydroxylase stimulator in the phenylalanine hydroxylation system.人苯丙氨酸羟化酶基因5'侧翼区肝细胞核因子1结合位点的鉴定：苯丙氨酸羟化酶刺激因子在苯丙氨酸羟化系统中的双重功能意义

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引用本文的文献

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PhhB, a Pseudomonas aeruginosa homolog of mammalian pterin 4a-carbinolamine dehydratase/DCoH, does not regulate expression of phenylalanine hydroxylase at the transcriptional level.PhhB是哺乳动物蝶呤4a-甲醇胺脱水酶/DCoH的铜绿假单胞菌同源物，它不在转录水平调节苯丙氨酸羟化酶的表达。

J Bacteriol. 1999 May;181(9):2789-96. doi: 10.1128/JB.181.9.2789-2796.1999.