食蟹猴和黑猩猩体内的中国I/疾控中心间日疟原虫株

The China I/CDC strain of Plasmodium malariae in Aotus monkeys and chimpanzees.

作者信息

Collins W E, Lobel H O, McClure H, Strobert E, Galland G G, Taylor F, Barreto A L, Roberto R R, Skinner J C, Adams S

机构信息

Malaria Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.

出版信息

Am J Trop Med Hyg. 1994 Jan;50(1):28-32. doi: 10.4269/ajtmh.1994.50.28.

DOI:10.4269/ajtmh.1994.50.28

PMID:8304570

Abstract

Five Aotus monkeys and two chimpanzees were infected with Plasmodium malariae isolated from a patient who acquired her infection approximately 50 years ago. All animals were splenectomized. The chimpanzees supported the highest parasite densities of 22,271/microliters and 18,544/microliters. Three Aotus monkeys with a previous history of infection with P. vivax had maximum parasite counts of from 1,818/microliters to 2,909/microliters, whereas two monkeys not previously infected had maximum parasite counts of 6,908/microliters. The establishment of new isolates in these animals aides the development of diagnostic probes and the identification of areas of antigenic variation within the species.

摘要

五只夜猴和两只黑猩猩感染了从一名大约50年前感染疟疾的患者身上分离出的间日疟原虫。所有动物均已接受脾切除术。黑猩猩体内的寄生虫密度最高，分别为每微升22271个和18544个。三只曾感染过间日疟原虫的夜猴，其最高寄生虫计数为每微升1818个至2909个，而两只未曾感染过的猴子，其最高寄生虫计数为每微升6908个。在这些动物中建立新的分离株有助于诊断探针的开发以及该物种内抗原变异区域的识别。