Ham B, Reichel M, Vogl T, Taupitz M, Wolf K J
Abteilung für Röntgendiagnostik und Nuklearmedizin, Klinikum Steglitz, Freie Universität Berlin.
Rofo. 1994 Jan;160(1):52-8.
The diagnostic value of superparamagnetic iron particles as a tissue-specific MR contrast medium of the reticulo-endothelial system was studied in 30 patients. All patients had liver metastases (maximally 5 known metastases on MR). The patients were examined on a 1.5 Tesla scanner before and after a slow intravenous injection of iron particles (AMI-25) at a dose of 15 mumol/kg. Contrast injection led to a significant reduction of signal strength in the liver parenchyma (p < or = 0.001) but not in the metastases. Contrast enhanced spin echo sequences (SE 2300/45) provided the most marked liver/tumour contrast, greater than the contrast values of T1- and T2-weighted images (p < or = 0.01). After the intravenous injection of iron particles, small metastases in particular are more easily demonstrated. A new, rapid T2-weighted pulse sequence (PSIF 10/15/15 degrees) results in the elimination of vascular signals and leads to better differentiation between lesions and intrahepatic vessels. The use of superparamagnetic iron particles as an MR contrast medium improves the demonstration of liver metastases.
对30例患者研究了超顺磁性铁颗粒作为网状内皮系统组织特异性磁共振造影剂的诊断价值。所有患者均有肝转移（磁共振成像最多发现5个已知转移灶）。在1.5特斯拉扫描仪上，对患者在缓慢静脉注射剂量为15μmol/kg的铁颗粒（AMI - 25）前后进行检查。注射造影剂后肝实质信号强度显著降低（p≤0.001），但转移灶信号强度未降低。对比增强自旋回波序列（SE 2300/45）提供了最明显的肝/肿瘤对比度，大于T1加权和T2加权图像的对比度值（p≤0.01）。静脉注射铁颗粒后，特别是小转移灶更容易显示。一种新的快速T2加权脉冲序列（PSIF 10/15/15°）可消除血管信号，使病变与肝内血管之间的区分更好。使用超顺磁性铁颗粒作为磁共振造影剂可改善肝转移灶的显示。
