Rongioletti F, Betti R, Crosti C, Rebora A
Department of Dermatology, University of Genoa, Italy.
Dermatology. 1994;188(1):28-31. doi: 10.1159/000247081.
Several entities, quite often similar, share keratotic papules, usually crateriform, along the border of the hands and feet as a common clinical finding. These conditions are acrokeratoelastoidosis of Costa, focal acral hyperkeratosis, acrokeratoelastoidosis of Matthews and Harman, mosaic acral keratosis, hereditary papulotranslucent acrokeratoderma, acrokeratoderma hereditarium punctatum, degenerative collagenous plaques of the hands, keratoelastoidosis marginalis and digital papular calcinosis. We describe two further cases of focal acral hyperkeratosis in two Caucasian women, review the clinical and histological features of the related conditions and suggest that some are variants of the same entity. We propose the simplified concept of marginal papular acrokeratodermas that may be divided into (1) the hereditary type (subdivided into that with and without elastorrhexis) and (2) the acquired type.
有几种情况，通常很相似，都有角化性丘疹，通常呈火山口状，沿手足边缘分布，这是一种常见的临床发现。这些病症包括科斯塔（Costa）肢端角化弹性组织变性、局限性肢端角化过度、马修斯（Matthews）和哈曼（Harman）肢端角化弹性组织变性、镶嵌性肢端角化病、遗传性丘疹性半透明肢端角化皮病、点状遗传性肢端角化皮病、手部退行性胶原斑块、边缘性角弹性组织变性和指状丘疹性钙化症。我们描述了两名白人女性的另外两例局限性肢端角化过度病例，回顾了相关病症的临床和组织学特征，并表明其中一些是同一实体的变体。我们提出了边缘性丘疹性肢端角化皮病的简化概念，可分为（1）遗传性类型（再细分为有和无弹性组织离解的类型）和（2）获得性类型。
