Kaiser R, Kaufmann R, Czygan M, Lang H, Lücking C H
Klinik und Poliklinik für Neurologie, Albert-Ludwigs-Universität Freiburg.
Clin Investig. 1993 Oct;71(10):795-801. doi: 10.1007/BF00190321.
Clinical and laboratory data from a patient with Guillain-Barré syndrome indicated a probable etiological correlation of polyradiculitis to the intravenous administration of streptokinase. Oligoclonal IgG bands in the cerebrospinal fluid and serum were shown to be specific for streptokinase. Serum titers of streptokinase were elevated 64-fold for IgG, 16-fold for IgM, and 4-fold for IgA compared to controls. Clinical symptoms of Guillain-Barré syndrome are thought to result from streptokinase antibody complex mediated damage to the local blood-nerve barrier. The pathogenic relevance of autoantibodies to albumin and proteins of the central and peripheral nervous systems, occurring early after onset of symptoms, remains to be determined.
一名吉兰-巴雷综合征患者的临床和实验室数据表明，多神经根炎可能与静脉注射链激酶存在病因学关联。脑脊液和血清中的寡克隆IgG带显示对链激酶具有特异性。与对照组相比，链激酶的血清滴度IgG升高了64倍，IgM升高了16倍，IgA升高了4倍。吉兰-巴雷综合征的临床症状被认为是由链激酶抗体复合物介导的对局部血-神经屏障的损伤所致。症状发作后早期出现的针对白蛋白以及中枢和周围神经系统蛋白质的自身抗体的致病相关性仍有待确定。
