印度北部主要组织相容性复合体基因与系统性红斑狼疮易感性
Major histocompatibility complex genes and susceptibility to systemic lupus erythematosus in northern India.
作者信息
Mehra N K, Pande I, Taneja V, Uppal S S, Saxena S P, Kumar A, Malaviya A N
机构信息
Histocompatibility and Immunogenetics Unit, All India Institute of Medical Sciences, New Delhi.
出版信息
Lupus. 1993 Oct;2(5):313-4. doi: 10.1177/096120339300200506.
Fifty-eight patients with systemic lupus erythematosus (SLE) from Northern India were tissue typed for HLA class I and II antigens. The results revealed an appreciable increase of HLA-DR4 (37.5%) among patients compared with controls (17.9%), P < 0.03. Additionally, haplotype B8-DR3 was encountered frequently in the patient group. The findings suggest an important role of MHC genes in influencing susceptibility to SLE.
对来自印度北部的58例系统性红斑狼疮（SLE）患者进行了HLA I类和II类抗原的组织分型。结果显示，与对照组（17.9%）相比，患者中HLA - DR4明显增加（37.5%），P < 0.03。此外，患者组中B8 - DR3单倍型出现频率较高。这些发现表明MHC基因在影响SLE易感性方面起重要作用。
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