Major histocompatibility complex genes and susceptibility to systemic lupus erythematosus in northern India.

作者信息

Mehra N K, Pande I, Taneja V, Uppal S S, Saxena S P, Kumar A, Malaviya A N

机构信息

Histocompatibility and Immunogenetics Unit, All India Institute of Medical Sciences, New Delhi.

出版信息

Lupus. 1993 Oct;2(5):313-4. doi: 10.1177/096120339300200506.

Fifty-eight patients with systemic lupus erythematosus (SLE) from Northern India were tissue typed for HLA class I and II antigens. The results revealed an appreciable increase of HLA-DR4 (37.5%) among patients compared with controls (17.9%), P < 0.03. Additionally, haplotype B8-DR3 was encountered frequently in the patient group. The findings suggest an important role of MHC genes in influencing susceptibility to SLE.