Merlini E, Beseghi U, De Castro R, Perlasca E, Podesta E, Riccipetitoni G
Department of Paediatric Surgery, Children's Hospital, Alessandria, Italy.
Br J Urol. 1993 Dec;72(6):969-71. doi: 10.1111/j.1464-410x.1993.tb16312.x.
A retrospective co-operative study was conducted among 6 Italian paediatric surgical departments to assess the results of different forms of treatment of vesicoureteric reflux in patients with neurogenic bladder. Between January 1980 and December 1989 we studied 641 neurogenic bladders in children, mainly due to spina bifida; reflux was detected in 199 patients with 263 refluxing ureters. Details of treatment were available for only 170 patients and they were divided into 2 main groups: conservative medical treatment (n = 127) and primary surgical treatment (n = 43). Medical treatment consisted mainly of clean intermittent catheterisation and the administration of appropriate drugs. In the surgical group 36 reimplantations, 6 cystostomies and 1 STING were performed. Fifteen patients underwent surgery as a secondary procedure. The results showed that approximately 50% of patients with reflux were cured by clean intermittent catheterisation and drug therapy. Ureteric reimplantation can be safely performed in patients with neurogenic bladder provided that a normally compliant, non-hyper-reflexic bladder can be achieved by means of drugs or by bladder augmentation with bowel.
一项回顾性合作研究在意大利的6个儿科外科部门开展,以评估神经源性膀胱患者不同形式的膀胱输尿管反流治疗结果。在1980年1月至1989年12月期间,我们研究了641例儿童神经源性膀胱,主要病因是脊柱裂;在199例患者中检测到反流,共263条输尿管存在反流。仅170例患者有治疗细节,他们被分为两个主要组:保守药物治疗(n = 127)和一期手术治疗(n = 43)。药物治疗主要包括清洁间歇性导尿和给予适当药物。手术组进行了36例输尿管再植术、6例膀胱造瘘术和1例STING手术。15例患者作为二期手术接受了手术。结果表明,约50%的反流患者通过清洁间歇性导尿和药物治疗得以治愈。对于神经源性膀胱患者,只要通过药物或肠道膀胱扩大术能够实现膀胱顺应性正常、无高反射性,就可以安全地进行输尿管再植术。