人脑深部核团中放射性示踪剂摄取的三维模拟。

3D simulations of radiotracer uptake in deep nuclei of human brain.

作者信息

Rousset O, Ma Y, Kamber M, Evans A C

机构信息

McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Quebec, Canada.

出版信息

Comput Med Imaging Graph. 1993 Jul-Oct;17(4-5):373-9. doi: 10.1016/0895-6111(93)90031-h.

DOI:10.1016/0895-6111(93)90031-h

PMID:8306312

Abstract

The accuracy of Positron Emission Tomography (PET) for measuring in vivo concentrations of radiolabelled pharmaceuticals is affected by the limited tomograph resolution. Using computer simulations, we developed a model reproducing the distribution of the tracer [18F]fluoroDOPA which is specifically taken up in the normal human striatum. Validation of the model was performed by comparing the simulated images with real PET scans of the same brain. The simulation was used to examine the effect of axial displacement of the brain relative to the PET imaging planes, and that of image contrast on signal recovery (partial volume effects).

摘要

正电子发射断层扫描（PET）测量放射性标记药物体内浓度的准确性受限于断层扫描仪的分辨率。我们通过计算机模拟开发了一个模型，该模型可再现示踪剂[18F]氟多巴在正常人类纹状体中的特异性摄取分布。通过将模拟图像与同一大脑的真实PET扫描图像进行比较，对该模型进行了验证。该模拟用于研究大脑相对于PET成像平面的轴向位移以及图像对比度对信号恢复（部分容积效应）的影响。