Squier M V
Department of Neuropathology, Radcliffe Infirmary, Oxford, UK.
Childs Nerv Syst. 1993 Nov;9(7):400-2. doi: 10.1007/BF00306192.
Type II lissencephaly is a rare cortical malformation associated with a number of clinical syndromes, including Walker-Warburg syndrome and some forms of congenital muscular dystrophy. The neuropathology of a 20-week fetus is described showing the pathogenesis of the malformation, which appears to result from abnormal migration of neurons through the pial-glial barrier into the leptomeninges.
II型无脑回畸形是一种罕见的皮质畸形,与多种临床综合征相关,包括沃克-沃尔伯格综合征和某些形式的先天性肌营养不良。本文描述了一名20周胎儿的神经病理学表现,显示了该畸形的发病机制,其似乎是由于神经元通过软膜-胶质屏障异常迁移至蛛网膜下腔所致。