膳食氯化钠对高血压大鼠肾小球和血管病变发展的影响。

Effect of dietary sodium chloride on the development of renal glomerular and vascular lesions in hypertensive rats.

Liu D T, Birchall I, Kincaid-Smith P, Whitworth J A

Department of Medicine, St George Hospital, University of New South Wales, Kogarah, Australia.

Clin Exp Pharmacol Physiol. 1993 Dec;20(12):763-72. doi: 10.1111/j.1440-1681.1993.tb03014.x.

Abstract

The hypothesis that high levels of NaCl in the diet aggravates hypertension-associated renal vascular lesions was examined in unilaterally nephrectomized deoxycorticosterone acetate treated (DOCA) and two kidney one clip (2K1C) hypertensive rats, as well as normotensive controls. 2. High NaCl diet significantly increased systolic blood pressure (SBP) in DOCA rats, but had little effect on SBP in normal control rats, and did not affect the rise of SBP in 2K1C rats. 3. High NaCl diet was associated with a higher percentage of glomerular lesions and renal arterial and arteriolar lesions in DOCA and 2K1C rats (P < 0.05). 4. Thus high NaCl intake exacerbated renal arterial and arteriolar and glomerular lesions in both DOCA and 2K1C hypertensive rats. In 2K1C rats this effect may be in part independent of blood pressure.

摘要

在单侧肾切除并用醋酸脱氧皮质酮（DOCA）处理的大鼠以及双肾单夹（2K1C）高血压大鼠和正常血压对照大鼠中，研究了饮食中高浓度氯化钠会加重高血压相关肾血管病变这一假说。2. 高盐饮食显著增加了DOCA大鼠的收缩压（SBP），但对正常对照大鼠的SBP影响很小，且不影响2K1C大鼠SBP的升高。3. 高盐饮食与DOCA和2K1C大鼠中更高比例的肾小球病变以及肾动脉和小动脉病变相关（P < 0.05）。4. 因此，高盐摄入加剧了DOCA和2K1C高血压大鼠的肾动脉、小动脉和肾小球病变。在2K1C大鼠中，这种作用可能部分独立于血压。