Crestani B, Jaccard A, Israël-Biet D, Couderc L J, Frija J, Clauvel J P
Immuno-Hematology Unit, Hôpital Saint Louis, Paris, France.
Chest. 1994 Feb;105(2):634-6. doi: 10.1378/chest.105.2.634.
A patient developed an interstitial pneumonitis while receiving chlorambucil for a chronic lymphocytic leukemia (cumulative dose, 8,340 mg). Withdrawal of drug treatment was followed by rapid improvement in the clinical condition. Bronchoalveolar lavage showed a T-lymphocytic alveolitis, whereas blood lymphocytes were predominantly of the B phenotype. The T-lymphocytic alveolitis persisted 6 weeks after drug therapy cessation with a predominant CD8+ phenotype, as observed in some hypersensitivity pneumonitis induced by drugs.
一名慢性淋巴细胞白血病患者在接受苯丁酸氮芥治疗（累积剂量8340毫克）时发生间质性肺炎。停药后临床状况迅速改善。支气管肺泡灌洗显示为T淋巴细胞性肺泡炎，而血液淋巴细胞主要为B表型。停药6周后，T淋巴细胞性肺泡炎持续存在，主要为CD8 +表型，这在一些药物引起的超敏性肺炎中可见。
