Hotz G, Novotny-Lenhard J, Kinzig M, Soergel F
Department of Maxillofacial and Plastic Surgery, University of Heidelberg, FRG.
Chemotherapy. 1994 Jan-Feb;40(1):65-9. doi: 10.1159/000239173.
The clinical efficacy of short-term antimicrobial prophylaxis with either one shot of ceftriaxone (1 g) or a course of 3 injections of a fixed combination of mezlocillin (2 g) and oxacillin (1 g) administered over 24 h was studied in a prospective randomized clinical study of 100 patients undergoing elective maxillofacial surgery. Tissue and plasma concentrations of the antibiotics were determined by high-pressure liquid chromatography in 6 tumor surgery patients from each treatment group. Statistical analysis showed the treatment group to be comparable both demographically and with respect to the types of surgery performed and the durations of the procedures. Only 1 patient in each group developed a postoperative wound infection. It is concluded that 1 g ceftriaxone given 30 min preoperatively meets the pharmacokinetic requirements for perioperative antimicrobial prophylaxis in maxillofacial surgery.
在一项针对100例行择期颌面外科手术患者的前瞻性随机临床研究中，研究了单次注射头孢曲松（1g）或在24小时内分3次注射美洛西林（2g）与苯唑西林（1g）固定组合这两种短期抗菌预防措施的临床疗效。通过高压液相色谱法测定了每个治疗组6例肿瘤手术患者的抗生素组织和血浆浓度。统计分析表明，治疗组在人口统计学、所进行的手术类型和手术持续时间方面具有可比性。每组仅1例患者发生术后伤口感染。结论是术前30分钟给予1g头孢曲松满足颌面外科围手术期抗菌预防的药代动力学要求。
