缺血性中风患者的白细胞和血小板聚集：一项病例对照研究。

Leukocyte and platelet aggregation in patients with ischemic stroke: a case-control study.

作者信息

Galante A, Pietroiusti A, Silvestrini M, Stanzione P, Domenici B, Bernardi G

机构信息

Medical Semiology and Methodology, Tor Vergata University, Rome, Italy.

出版信息

Eur Neurol. 1993;33(6):442-5. doi: 10.1159/000116990.

DOI:10.1159/000116990

PMID:8307066

Abstract

We evaluated simultaneously leukocyte and platelet aggregation in 40 untreated patients soon after atherothrombotic stroke and in 40 healthy controls matched for age, sex and risk factors. Both leukocyte and platelet aggregation were significantly increased in patients relative to controls (p < 0.01 and p < 0.02, respectively). However, whereas leukocyte aggregation was positive in a significantly higher proportion of patients with subsequent major neurological deficit compared to those with minor deficit (71% vs. 19%; p = 0.04), platelet aggregation was similar in the two patient groups. These data suggest different patterns of activation of leukocyte and platelet aggregation in patients with ischemic stroke. This finding may have pathophysiological and clinical implications.

摘要

我们同时评估了40例动脉粥样硬化性血栓形成性卒中后未经治疗的患者以及40名年龄、性别和风险因素相匹配的健康对照者的白细胞和血小板聚集情况。与对照组相比，患者的白细胞和血小板聚集均显著增加（分别为p < 0.01和p < 0.02）。然而，与轻度神经功能缺损的患者相比，随后出现严重神经功能缺损的患者白细胞聚集呈阳性的比例显著更高（71%对19%；p = 0.04），而两组患者的血小板聚集情况相似。这些数据表明缺血性卒中患者白细胞和血小板聚集的激活模式不同。这一发现可能具有病理生理学和临床意义。