Velardo A, Zizzo G, Della Casa L, Coletta F, Pantaleoni M, Marrama P, Del Rio G
Department of Endocrinology, University of Modena, Italy.
Exp Clin Endocrinol. 1993;101(4):243-8. doi: 10.1055/s-0029-1211239.
It has been shown that thyroid hormones are positive regulators of GH synthesis and secretion. The serum GH response to stimuli seems to be influenced either by sex or by spontaneous hypothalamic rhythm. The growth hormone responses to clonidine administration (4 micrograms/kg) have been therefore studied in a group of female patients with thyroid disease (seven hyperthyroid and five hypothyroid) before and after the achievement of the euthyroid state. In hyperthyroid patients both basal and clonidine-stimulated GH levels were similar to normal subjects; the achievement of euthyroidism did not modify the GH response to clonidine. Serum GH peaks after clonidine were lower in hypothyroids patients than in hyperthyroids and normal subjects; the GH response to alpha 2-agonist administration did not change during thyroid replacement therapy. The GH response to clonidine was not influenced by the GH secretory status in the preceding hour.
研究表明，甲状腺激素是生长激素（GH）合成与分泌的正向调节因子。血清GH对刺激的反应似乎受性别或下丘脑自发节律的影响。因此，我们对一组患有甲状腺疾病的女性患者（7例甲亢患者和5例甲减患者）在达到甲状腺功能正常状态前后，进行了可乐定给药（4微克/千克）时生长激素反应的研究。甲亢患者的基础GH水平和可乐定刺激后的GH水平均与正常受试者相似；甲状腺功能正常化并未改变GH对可乐定的反应。甲减患者可乐定给药后的血清GH峰值低于甲亢患者和正常受试者；在甲状腺替代治疗期间，对α2激动剂给药的GH反应没有变化。GH对可乐定的反应不受前一小时GH分泌状态的影响。
