Saupe J, Ronden J E, Soute B A, Vermeer C
IIIrd Department of Internal Medicine, Moabit Hospital, Berlin, Germany.
FEBS Lett. 1994 Jan 31;338(2):143-6. doi: 10.1016/0014-5793(94)80352-8.
Decyl-ubiquinone and decyl-plastoquinone were used as model compounds to test the potential effect of quinone derivatives on two enzymes of the vitamin K cycle in vitro. Substantial inhibition of gamma-glutamate carboxylase was found, whereas vitamin K-epoxide reductase was inhibited to a much lesser extent. The inhibitory effect of both decylquinones was eliminated in a time-dependent way by solubilized microsomes, but not by purified carboxylase. Since a wide variety of prenylquinones occur as micronutrients, these results are of potential relevance for the effects of natural quinones in the human diet.
癸基泛醌和癸基质体醌被用作模型化合物，以在体外测试醌衍生物对维生素K循环的两种酶的潜在作用。发现γ-谷氨酸羧化酶受到显著抑制，而维生素K环氧化物还原酶的抑制程度要小得多。两种癸基醌的抑制作用可被溶解的微粒体以时间依赖性方式消除，但不能被纯化的羧化酶消除。由于多种异戊二烯基醌作为微量营养素存在，这些结果对于人类饮食中天然醌的作用具有潜在的相关性。
