A novel gene delivery system using EGF receptor-mediated endocytosis.
作者信息
Chen J, Gamou S, Takayanagi A, Shimizu N
机构信息
Department of Molecular Biology, Keio University School of Medicine, Tokyo, Japan.
出版信息
FEBS Lett. 1994 Jan 31;338(2):167-9. doi: 10.1016/0014-5793(94)80357-9.
PMID:8307175
Abstract
A monoclonal antibody to the human epidermal growth factor (EGF) receptor was conjugated with polylysine and the resulting conjugate was affinity-linked with DNA (gene). This novel gene delivery system utilizes receptor-mediated endocytosis and would be especially suitable for gene therapy for EGF receptor-overproducing squamous cell carcinomas.
摘要
Zotero 插件