Couvreur Patrick, Vauthier Christine
Laboratoire de Physico-chimie, Pharmacotechnie et Biopharmacie, UMR CNRS 8612, Université de Paris Sud, 5 Rue J.B. Clément, 92 296, Chatenay-Malabry Cedex, France.
Pharm Res. 2006 Jul;23(7):1417-50. doi: 10.1007/s11095-006-0284-8. Epub 2006 Jun 21.
The purpose of this expert review is to discuss the impact of nanotechnology in the treatment of the major health threats including cancer, infections, metabolic diseases, autoimmune diseases, and inflammations. Indeed, during the past 30 years, the explosive growth of nanotechnology has burst into challenging innovations in pharmacology, the main input being the ability to perform temporal and spatial site-specific delivery. This has led to some marketed compounds through the last decade. Although the introduction of nanotechnology obviously permitted to step over numerous milestones toward the development of the "magic bullet" proposed a century ago by the immunologist Paul Ehrlich, there are, however, unresolved delivery problems to be still addressed. These scientific and technological locks are discussed along this review together with an analysis of the current situation concerning the industrial development.
本专家综述的目的是探讨纳米技术在治疗包括癌症、感染、代谢疾病、自身免疫性疾病和炎症在内的主要健康威胁方面的影响。事实上，在过去30年中，纳米技术的爆炸式增长引发了药理学领域的挑战性创新，主要推动力是实现时空特异性递送的能力。这在过去十年中催生了一些已上市的化合物。尽管纳米技术的引入显然使我们朝着免疫学家保罗·埃利希一个世纪前提出的“神奇子弹”的发展跨越了许多里程碑，但仍有一些未解决的递送问题有待解决。本综述将讨论这些科学和技术障碍，并分析工业发展的现状。
