Binder M, Zeiller P
Luitpold Pharma GmbH, München.
Fortschr Med. 1993 Nov 30;111(33):530-2.
An overview of the literature on the effects of salicylic acid and its derivatives with particular consideration being given to their antiinflammatory properties is presented. While acetylsalicylic acid, in common with most non-steroidal anti-inflammatory drugs, has a marked inhibitory effect on cyclooxygenase in vitro, salicylic acid only weakly inhibits this enzyme. Animal inflammation models, however, have shown that the two substances are comparable in terms of efficacy. It is therefore assumed that the antiinflammatory properties of salicylic acid and its derivatives are also based on prostaglandin-independent mechanisms. Both salicylates and salicylic acid are used for topical applications. Their penetration into deeper tissue layers, as also their efficacy after local application have been demonstrated in both animal studies and clinical trials.
本文综述了水杨酸及其衍生物的作用相关文献，特别关注了它们的抗炎特性。虽然乙酰水杨酸与大多数非甾体抗炎药一样，在体外对环氧化酶有显著抑制作用，但水杨酸对该酶的抑制作用较弱。然而，动物炎症模型表明，这两种物质在疗效方面具有可比性。因此，推测水杨酸及其衍生物的抗炎特性也基于不依赖前列腺素的机制。水杨酸盐和水杨酸均用于局部应用。在动物研究和临床试验中均已证明它们可渗透到更深的组织层，以及局部应用后的疗效。
