• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Antibodies to major histocompatibility complex class II inhibit proliferation, but increase production of soluble CD23 in lymphoblastoid B-cell lines.针对主要组织相容性复合体II类的抗体可抑制增殖，但会增加淋巴母细胞样B细胞系中可溶性CD23的产生。
Immunology. 1993 Dec;80(4):593-7.
2
CD23/CD21 interaction is required for presentation of soluble protein antigen by lymphoblastoid B cell lines to specific CD4+ T cell clones.淋巴母细胞样B细胞系将可溶性蛋白抗原呈递给特异性CD4+T细胞克隆需要CD23/CD21相互作用。
Eur J Immunol. 1994 Dec;24(12):2982-6. doi: 10.1002/eji.1830241209.
3
T lymphocyte culture established by repeated stimulation with the autologous lymphoblastoid line. MHC class II restricted interactions with B blasts.
Mol Biol Med. 1984 Aug;2(4):285-99.
4
Functional implication for the topographical relationship between MHC class II and the low-affinity IgE receptor: occupancy of CD23 prevents B lymphocytes from stimulating allogeneic mixed lymphocyte responses.MHC II类分子与低亲和力IgE受体之间拓扑关系的功能意义：CD23的占据可阻止B淋巴细胞刺激同种异体混合淋巴细胞反应。
Eur J Immunol. 1990 Nov;20(11):2465-9. doi: 10.1002/eji.1830201116.
5
Cross-linking of HLA class II antigens modulates the release of tumor necrosis factor-alpha by the EBV-B lymphoblastoid cell line JY.人类白细胞抗原II类抗原的交联调节EB病毒B淋巴母细胞系JY释放肿瘤坏死因子-α。
J Immunol. 1993 Nov 15;151(10):5115-22.
6
Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the surface of a B cell line JY.B细胞系JY表面的MHC I类、MHC II类、CD20和四跨膜蛋白分子（CD53、CD81和CD82）的超分子复合物
J Immunol. 1996 Oct 1;157(7):2939-46.
7
Tetraspan microdomains distinct from lipid rafts enrich select peptide-MHC class II complexes.与脂筏不同的四跨膜微区富集特定的肽 - 主要组织相容性复合体II类复合物。
Nat Immunol. 2002 Jan;3(1):61-8. doi: 10.1038/ni750. Epub 2001 Dec 17.
8
Cross-linking of MHC class II molecules interferes with phorbol 12,13-dibutyrate-induced differentiation of resting B cells by inhibiting Rac-associated ROS-dependent ERK/p38 MAP kinase pathways leading to NF-kappaB activation.MHC II类分子的交联通过抑制与Rac相关的活性氧依赖性ERK/p38丝裂原活化蛋白激酶途径，干扰佛波醇12,13 -二丁酸酯诱导的静息B细胞分化，该途径会导致核因子κB活化。
Mol Immunol. 2007 Mar;44(7):1577-86. doi: 10.1016/j.molimm.2006.08.017. Epub 2006 Oct 2.
9
A caspase-independent pathway of MHC class II antigen-mediated apoptosis of human B lymphocytes.MHC II类抗原介导的人B淋巴细胞凋亡的非半胱天冬酶依赖性途径。
J Immunol. 1999 Oct 15;163(8):4115-24.
10
Induction of autologous CD4- and CD8-mediated T-cell responses against acute lymphocytic leukemia cell line using apoptotic tumor cell-loaded dendritic cells.利用负载凋亡肿瘤细胞的树突状细胞诱导针对急性淋巴细胞白血病细胞系的自体CD4和CD8介导的T细胞反应。
Exp Hematol. 2006 Feb;34(2):197-207. doi: 10.1016/j.exphem.2005.11.004.

本文引用的文献

1
Structure and function of Fc receptors for IgE on lymphocytes, monocytes, and macrophages.淋巴细胞、单核细胞和巨噬细胞上IgE的Fc受体的结构与功能。
Adv Immunol. 1984;35:61-88. doi: 10.1016/s0065-2776(08)60574-x.
2
The specific direct interaction of helper T cells and antigen-presenting B cells.辅助性T细胞与抗原呈递B细胞之间特定的直接相互作用。
Proc Natl Acad Sci U S A. 1986 Aug;83(16):6080-3. doi: 10.1073/pnas.83.16.6080.
3
Antibodies reactive with class II antigens encoded for by the major histocompatibility complex inhibit human B cell activation.与主要组织相容性复合体编码的II类抗原发生反应的抗体可抑制人类B细胞的激活。
J Immunol. 1986 Apr 1;136(7):2375-81.
4
The interaction between protein-derived immunogenic peptides and Ia.蛋白质衍生的免疫原性肽与Ia之间的相互作用。
Immunol Rev. 1987 Aug;98:115-41. doi: 10.1111/j.1600-065x.1987.tb00522.x.
5
Ia binding ligands and cAMP stimulate nuclear translocation of PKC in B lymphocytes.Ia结合配体和环磷酸腺苷（cAMP）刺激B淋巴细胞中蛋白激酶C（PKC）的核转位。
Nature. 1987;327(6123):629-32. doi: 10.1038/327629a0.
6
The low-affinity receptor for IgE (CD23) on B lymphocytes is spatially associated with HLA-DR antigens.B淋巴细胞上的IgE低亲和力受体（CD23）在空间上与HLA-DR抗原相关联。
J Exp Med. 1988 Jan 1;167(1):57-72. doi: 10.1084/jem.167.1.57.
7
Antigen presentation abrogated in cells expressing truncated Ia molecules.在表达截短的Ia分子的细胞中，抗原呈递被消除。
J Immunol. 1989 Mar 1;142(5):1444-7.
8
Interleukin 4 and soluble CD23 as progression factors for human B lymphocytes: analysis of their interactions with agonists of the phosphoinositide "dual pathway" of signalling.白细胞介素4和可溶性CD23作为人B淋巴细胞的进展因子：对它们与磷酸肌醇“双信号通路”激动剂相互作用的分析
Eur J Immunol. 1988 Oct;18(10):1561-5. doi: 10.1002/eji.1830181014.
9
A functional role for signal transduction via the cytoplasmic domains of MHC class II proteins.通过MHC II类蛋白的细胞质结构域进行信号转导的功能作用。
J Immunol. 1989 Aug 1;143(3):808-12.
10
Growth inhibition of Epstein-Barr virus-transformed B cells by anti-HLA-DR antibody L243: possible relationship to L243-induced down-regulation of CD23 antigen expression.抗HLA-DR抗体L243对爱泼斯坦-巴尔病毒转化的B细胞的生长抑制作用：与L243诱导的CD23抗原表达下调的可能关系。
Cell Immunol. 1989 Apr 15;120(1):21-30. doi: 10.1016/0008-8749(89)90171-8.

针对主要组织相容性复合体II类的抗体可抑制增殖，但会增加淋巴母细胞样B细胞系中可溶性CD23的产生。

Antibodies to major histocompatibility complex class II inhibit proliferation, but increase production of soluble CD23 in lymphoblastoid B-cell lines.

作者信息

Hajeer A H, Snowden N, Wilson P, Drover S, Ollier W E

机构信息

ARC ERU, University of Manchester Medical School, U.K.

出版信息

Immunology. 1993 Dec;80(4):593-7.

PMID:8307609
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1422249/
Abstract

Class II major histocompatibility complex (MHC) proteins bind and present peptide antigens to T cells. Moreover, their function as signal transduction molecules has recently been emphasized. Here we used Epstein-Barr virus (EBV)-transformed B-cell lines (B-LCL) in experiments to investigate the changes induced by binding of specific antibodies to HLA-DR molecules. Binding of the antibodies induced, in an allele-specific manner, striking non-cytotoxic inhibition of B-LCL proliferation. This inhibition was associated with an increase in shedding of soluble CD23. These findings provide further evidence for the function of MHC class II proteins as signal transduction molecules which may be important in B-cell activation.

摘要

II类主要组织相容性复合体（MHC）蛋白结合并将肽抗原呈递给T细胞。此外，它们作为信号转导分子的功能最近也得到了强调。在这里，我们在实验中使用了爱泼斯坦-巴尔病毒（EBV）转化的B细胞系（B-LCL），以研究特异性抗体与HLA-DR分子结合所诱导的变化。抗体的结合以等位基因特异性方式诱导了B-LCL增殖的显著非细胞毒性抑制。这种抑制与可溶性CD23脱落的增加有关。这些发现为MHC II类蛋白作为信号转导分子的功能提供了进一步的证据，这在B细胞激活中可能很重要。