在耐受小鼠中进行人淋巴细胞的异种移植。
Xenogenic transfer of human lymphocytes in tolerized mice.
作者信息
Gore M M, Kolhapure R M, Govardhan M K, Banerjee K
机构信息
National Institute of Virology, Pune, India.
出版信息
Immunology. 1993 Dec;80(4):664-5.
Abstract
Female nu/+ or BALB/c mice were immunized with human peripheral blood lymphocytes (PBL) before and during pregnancy. Pups born to these mothers were inoculated with human PBL or human fetal bone marrow and thymus cells. Tolerization of the pups to human PBL was observed without graft-versus-host reaction. Presence of human immunoglobulins was observed in the pups for 3-4 weeks. Human T cells also could be detected for a period of 3-4 months in these mice.
摘要
雌性nu/+或BALB/c小鼠在怀孕前及怀孕期间用人外周血淋巴细胞（PBL）进行免疫。这些母鼠所生的幼崽接种人PBL或人胎儿骨髓及胸腺细胞。观察到幼崽对人PBL产生耐受，无移植物抗宿主反应。在幼崽中观察到人类免疫球蛋白存在3 - 4周。在这些小鼠中还能在3 - 4个月的时间段内检测到人类T细胞。
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