Brewster D
Public Health Medicine, Communicable Diseases Unit, Ruchill Hospital, Glasgow, Scotland.
Health Bull (Edinb). 1993 Nov;51(6):385-93.
Immunisation against Haemophilus influenzae b (Hib) was added to the UK childhood vaccination schedule on 1 October 1992. Based on reports of laboratory isolations from blood and/or CSF, the epidemiology of Haemophilus influenzae invasive disease in Scotland during the last full year before immunisation (1991) is reviewed. In children aged under five years the estimated incidence of infection (25.5 per 100,000) is higher than that previously reported from Scotland, but lower than estimates from Glasgow and other UK studies. However, the age-sex and seasonal distribution is consistent with previous surveys. As in England and Wales, there appears to be regional variation in incidence within Scotland, although this may simply reflect differences in the completeness of laboratory reporting. In addition to 113 laboratory reports of H. influenzae invasive infection, a retrospective search of hospital discharge data and death registrations identified a further 51 and two cases respectively, some of whom may be genuine. In spite of reservations about hospital discharge data, this raises the possibility that there may be an element of under-reporting by laboratories. With the advent of record linkage of hospital discharge data, it would be prudent to monitor the impact of the Hib vaccine programme using this data source in addition to laboratory reports and death registrations.
b型流感嗜血杆菌（Hib）免疫接种于1992年10月1日被纳入英国儿童疫苗接种计划。基于从血液和/或脑脊液中实验室分离报告，对免疫接种前最后一整年（1991年）苏格兰侵袭性流感嗜血杆菌病的流行病学进行了回顾。在五岁以下儿童中，估计感染发病率（每10万例中有25.5例）高于此前苏格兰报告的发病率，但低于格拉斯哥及英国其他研究的估计值。然而，年龄-性别和季节分布与此前调查一致。与英格兰和威尔士一样，苏格兰内部发病率似乎存在地区差异，尽管这可能仅仅反映了实验室报告完整性的差异。除了113份流感嗜血杆菌侵袭性感染的实验室报告外，对医院出院数据和死亡登记的回顾性搜索分别又发现了51例和2例病例，其中一些可能是真实的。尽管对医院出院数据有所保留，但这增加了实验室报告可能存在漏报情况的可能性。随着医院出院数据记录链接的出现，除了实验室报告和死亡登记外，利用这一数据源监测Hib疫苗计划的影响将是审慎之举。
