Nahas A D, Krynicki V
J Nerv Ment Dis. 1977 Jan;164(1):66-9. doi: 10.1097/00005053-197701000-00012.
The effect of methylphenidate on sleep pattern was assessed in four hyperactive children. Two nights of sleep were recorded before drug administration, sleep was again recorded on the 1st and 21st nights during drug administration, and also on the 1st and 2nd nights of drug withdrawal. All patients showed behavioral improvement during drug administration; however, no drug effect was seen when standard sleep variables such as sleep stages and sleep time were examined. This analysis was supplemented by an examination of the REM cycle and computer extraction of the delta cycle; both are ultradian (40 to 140 minutes) rhythms. These rhythms were found to be intact in hyperactive patients. Although the REM cycle was not affected by drug administration or withdrawal, a trend toward lengthening of the delta cycle was found on drug withdrawal.
对4名多动症儿童评估了哌甲酯对睡眠模式的影响。在给药前记录两晚的睡眠情况，在给药期间的第1晚和第21晚以及停药后的第1晚和第2晚再次记录睡眠情况。所有患者在给药期间行为均有改善；然而，在检查诸如睡眠阶段和睡眠时间等标准睡眠变量时未发现药物效应。通过对快速眼动周期的检查和δ周期的计算机提取对该分析进行了补充；两者均为超日节律（40至140分钟）。发现这些节律在多动症患者中是完整的。虽然快速眼动周期不受给药或停药的影响，但在停药时发现δ周期有延长的趋势。
