自由基与抗氧化剂补充：它们在年龄相关性黄斑变性中作用的综述
Free radicals and antioxidant supplementation: a review of their roles in age-related macular degeneration.
作者信息
van der Hagen A M, Yolton D P, Kaminski M S, Yolton R L
机构信息
Pacific University, College of Optometry, Forest Grove, OR 97116.
出版信息
J Am Optom Assoc. 1993 Dec;64(12):871-8.
BACKGROUND
Age-related macular degeneration (ARMD) is a major cause of blindness in the elderly. Unfortunately, no proven form of treatment is currently available for the dry, atrophic form of ARMD seen in more than 90 percent of patients with this condition.
METHODS
A recent theory suggests that ARMD is associated with damage to the retina caused by free radicals. If this is correct, it is possible that the damage could be prevented or moderated by supplementing the diet with specific antioxidant vitamins and minerals that enhance the body's natural defenses against free radicals.
RESULTS AND CONCLUSION
This paper reviews the literature regarding the pathogenesis of ARMD and presents a rationale for its management or prevention by the use of supplemental vitamins and minerals.
背景
年龄相关性黄斑变性（ARMD）是老年人失明的主要原因。不幸的是，目前尚无经证实的治疗方法可用于治疗90%以上患有这种疾病的干性萎缩型ARMD。
方法
最近的一种理论认为，ARMD与自由基对视网膜造成的损伤有关。如果这一观点正确，那么通过在饮食中补充特定的抗氧化维生素和矿物质来增强机体对自由基的天然防御能力，就有可能预防或减轻这种损伤。
结果与结论
本文回顾了有关ARMD发病机制的文献，并提出了使用补充性维生素和矿物质进行管理或预防的理论依据。
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