氧疗与透明膜病：高氧对肺超氧化物歧化酶活性的影响及血浆或血清的介导作用。

Oxygen therapy and hyaline membrane disease: the effect of hyperoxia on pulmonary superoxide dismutase activity and the mediating role of plasma or serum.

作者信息

Frank L, Autor A P, Roberts R J

出版信息

J Pediatr. 1977 Jan;90(1):105-10. doi: 10.1016/s0022-3476(77)80781-6.

Abstract

In vitro and in vivo hyperoxic exposure of the lungs of normal immature animals resulted in a rapid increase of pulmonary superoxide dismutase activity. The increase of pulmonary SOD activity with in vitro hyperoxic exposure requires the presence of plasma or serum in the incubation medium. Twenty-three out of 26 plasma samples from premature infants without hyaline membrane disease were found to support the hyperoxic increaase of pulmonary SOD activity, whereas only five of 15 plasma samples from infants with HMD were effective. A defective plasma-lung interaction in infants with HMD may result in an inability to increase pulmonary levels of this presumed protective enzyme during hyperoxic therapy.

摘要

对正常未成熟动物的肺进行体外和体内高氧暴露，会导致肺超氧化物歧化酶活性迅速增加。体外高氧暴露导致的肺超氧化物歧化酶（SOD）活性增加，需要在孵育培养基中存在血浆或血清。在26份来自无透明膜病的早产儿的血浆样本中，有23份被发现可支持肺SOD活性的高氧增加，而在15份来自患有透明膜病的婴儿的血浆样本中，只有5份有效。患有透明膜病的婴儿中血浆-肺相互作用存在缺陷，可能导致在高氧治疗期间无法增加这种假定的保护酶的肺水平。