Early antibody response following vasectomy is related to fertility after vasovasostomy in glucocorticoid-treated and untreated Lewis rats.

The influence of treatment with a glucocorticoid on antisperm antibodies and fertility after vasectomy and vasovasostomy was studied in Lewis rats. Animals received a bilateral vasectomy followed 4 weeks later by bilateral vasovasostomy. Treatment with methylprednisolone for two months beginning at the time of the vasovasostomy resulted in a decrease in antisperm antibodies compared with nontreated vasovasostomized animals, but there was no difference in fertility between treated and nontreated vasovasostomized groups. However, when fertile vasovasostomized animals from treated and nontreated groups were compared with infertile vasovasostomized animals, antisperm antibodies were found to be significantly lower in fertile rats 2, 4 and 8 weeks after vasectomy, while antibodies did not differ between fertile and infertile animals at the end of the study (12 weeks). The observation that differences in antisperm antibodies appeared shortly after vasectomy, preceding either vasovasostomy or treatment, suggests that changes occurring very early after vasectomy have far-reaching effects and are among the factors that influence future fertility after vasovasostomy.